Resident Evil 4 Remake bug affecting progress in Chapter 12 will be patched by Capcom
Capcom has warned Resident Evil 4 Remake players of a rather serious but rare bug in Chapter 12 that could stop your game from progressing.
You can keep the bug from triggering, and be sure to have a save handy before starting Chapter 12. The workaround is posted below the video and is as non-spoilery as possible.
According to Capcom, there is a cutscene that will play at the beginning of Chapter 12, after which you will receive a key item. This item is needed to progress, and the bug is activated when you start attacking with your knife. Doing so could keep you from obtaining the needed item.