All hail Garlic Jr., the only Dragon Ball villain who actually won (kinda)
This little blue dude is an A-hole
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This little blue dude is an A-hole
Scientists have pinpointed pieces of DNA which, they say, act like Bond villains in the way they help cancers spread. These microscopic agents have also been shown to be responsible for helping tumours gain resistance to anti-cancer drugs. The discovery of these bits of genetic material — known as extrachromosomal DNA or ecDNA — could revolutionise the treatments of some of the most aggressive tumours that affect people today, add the researchers….
Made up of tiny loops of DNA, these genetic villains survive outside the chromosomes which are our cells’ main repositories of genetic material…. “We have found that ecDNA act as cancer-causing genes that have somehow separated themselves from a person’s chromosomes and have started to behave in ways that circumvent the normal rules of genetics,” said Stanford university geneticist Howard Chang. “They behave like villains in a Bond film. At first, in a film, you see different explosions, killings and disasters occurring and you don’t know why they are happening or who is responsible. Then, at some point, you finally meet the villain who is revealed to be the agent of all this mayhem.”
They also seem to resemble the Bond henchman who re-appears at the end of the movie. Professor Paul Mischel of California’s Stanford University says that when treating the most aggressive cancers, “The vulnerable gene had quickly disappeared when threatened by cancer drugs and was hidden in ecDNA. Then it reappeared once it was safe for it to start causing damage again.”
Mischel calls the discovery “a gamechanger,” identifying the culprit “responsible for a large number of the more advanced, most serious cancers affecting people today. If we can block their activities, we can block the spread of these cancers.”
And that hope was echoed by Dr Mariam Jamal-Hanjani of University College London Cancer Institute “The crucial point is that once we have found the cause of the problem then it becomes possible to develop and try out all sorts of drugs and therapies to tackle that.”
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“The discovery of how these bits of DNA behave inside our bodies is a gamechanger,” said Professor Paul Mischel of California’s Stanford university, one of the leaders of the programme. “We believe they are responsible for a large number of the more advanced, most serious cancers affecting people today. If we can block their activities, we can block the spread of these cancers.”
Read more of this story at Slashdot.
Mental organism designed only for kexplaining comics lore
It’s a tragedy in five parts
Writer Harry “Hbomberguy” Brewis and artist Skutch tell the story of Ned Ludd
And she’s getting her own graphic novel before the next season premieres
Well, Hogwarts Legacy mods are out already, as the Harry Potter RPG game launches on Steam and the Epic Games Store. You might be expecting new spells, visual updates, or a reskin so you can play as Harry himself. Nah. Channelling Bethesda, Skyrim, and some of the best PC games of the last decade, Hogwarts Legacy mods are steaming ahead with Thomas the Tank Engine.
MORE FROM PCGAMESN: Hogwarts Legacy release date, All Hogwarts Legacy spells, Hogwarts Legacy system requirements
Consider the potential of an infinitely respawnable villain — and how he could improve on Star Wars and the MCU
PRINCE Harry called Queen Camilla “dangerous” in his second TV interview of the night.
The Duke of Sussex, 38, also told presenter Anderson Cooper on CBS’s 60 Minutes that “there was going to be bodies left in the street” as his step-mum rose to become Queen Consort.
Prince Harry called Queen Camilla ‘dangerous’[/caption]
He also parroted claims she was the ‘other woman’[/caption]
He wrote his interests were sacrificed for Camilla’s PR alter[/caption]
And he accused Camilla of showing an “open willingness” to trade information with the press as she campaigned to marry Charles.
The new interview aired on Sunday night ahead of the book’s release on Tuesday.
Asked why he referred to Camilla, 75, as dangerous in Spare, Harry said: “Because of the need for her to rehabilitate her image.
“That made her dangerous because of the connections that she was forging within the British press.
“And there was open willingness on both sides to trade information.
“And with a family built on hierarchy, and with her, on the way to being Queen Consort, there was going to be people or bodies left in the street because of that.”
Earlier in the interview, he parroted claims of her being the “other woman”, adding: “She was the villain. She was the third person in their marriage. She needed to rehabilitate her image.”
Harry also addressed his admission in the book that he had taken psychedelic drugs including Ayahuasca and psilocybin mushrooms.
He claimed that it helped him to deal with the scars left by his mother Diana’s death in a car crash in August 1997.
He said: “I would never recommend people to do this recreationally.
“But doing it with the right people if you are suffering from a huge amount of loss, grief or trauma, then these things have a way of working as a medicine.
“For me, they cleared the windscreen, the windshield, the misery of loss.
“They cleared away this idea that I had in my head that I needed to cry to prove to my mother that I missed her.
“When in fact, all she wanted was for me to be happy.”
Harry also claimed in the interview that he was not invited to join the rest of the Royal Family on a plane to Balmoral when the Queen died in September.
He explained: “I asked my brother, I said, ‘What are your plans? How are you and Kate getting up there?’
“And then, a couple of hours later, you know, all of the family members that live within the Windsor and Ascot area were jumping on a plane together, a plane with 12, 14, maybe 16 seats.”
Anderson Cooper asked: “You were not invited on that plane?”
Harry answered: “I was not invited.”
The interview is round two of the Duke trashing the family after he sat down with ITV’s Tom Bradby.
He told his journalist friend that Prince William and Princess Catherine failed to welcome Meghan Markle into the family because of stereotypes about her as a biracial American actress.
He also said the King was never made to be single dad before hitting back at claims he was scathing towards Queen Camilla.
The Duke then said he no longer recognises his own family, before conceding that they probably feel the same about him.
And he sensationally denied ever calling his relatives racist – despite telling Oprah Winfrey a member of the family had “concerns” about his son Archie’s skin colour.
Millions of ITV viewers were stunned to see Harry distance himself from incendiary comments made on US telly to Oprah Winfrey in 2021.
Bradby had asked Harry, 38, to elaborate on the Oprah interview in which “you accused members of your family of racism”.
Millions of viewers were left open-mouthed when Harry replied: “No I didn’t.”
Even Bradby looked stunned as the Duke of Sussex passed the blame elsewhere, muttering: “The British press said that.”
Harry then dug an even bigger hole by asking Bradby: “Did Meghan ever mention that they’re racist?” Bradby repeated Meghan’s claim that there “troubling comments about Archie’s skin colour.”
Harry, promoting his book Spare, replied: “There was – there was concern about his skin colour.”
He was then asked: “Wouldn’t you describe that as essentially racist?”
Harry cryptically responded: “I wouldn’t, not having lived within that family.”
He interrupted Brady’s attempts to question further, and suggested it was “unconscious bias”, not racism, and they can now ”learn and grow” and be “part of the solution”, instead of the problem.
He was then asked: “Wouldn’t you describe that as essentially racist?”
Harry cryptically responded: “I wouldn’t, not having lived within that family.”
He interrupted Bradby’s attempts to question further, and suggested it was “unconscious bias”, not racism, and they can now ”learn and grow” and be “part of the solution” instead of the problem.
He also repeated his previous claim that he will “never talk about” who made the comments about Archie’s skin colour.